September 2023 HighlightsBy Anonymous / October 2, 2023 Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity Activity-based profiling of cullin–RING E3 networks by conformation-specific probesDevelopment and Applications of Chimera Platforms for Tyrosine Phosphorylation PROTAC chemical probes for histone deacetylase enzymesIncorporating a β-hairpin sequence motif to increase intracellular stability of a peptide-based PROTAC Central Nervous System Targeted Protein DegradersDevelopment of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 PathwayDiscovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy PROTAC for agriculture: learning from human medicine to generate new biotechnological weed control solutionsDegradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs Design principles for cyclin K molecular glue degradersMammalian autophagosomes form from finger-like phagophores Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate CancerVHL-Modified PROteolysis TArgeting Chimeras (PROTACs) as a Strategy to Evade Metabolic Degradation in In Vitro Applications Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) DegradersExploring the target scope of KEAP1 E3 ligase-based PROTACs Recent Progress on Microtubule Degradation AgentsDesign, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5 Targeted protein degradation in drug development: Recent advances and future challengesChemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry Proteomic approaches advancing targeted protein degradationStructural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen Receptor Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative ApproachesPhotoactivated Protein Degrader for Optical Control of Synaptic Function Defining E3 ligase–substrate relationships through multiplex CRISPR screeningSelective Protein of Interest Degradation through the Split-and-Mix Liposome Proteolysis Targeting Chimera Approach Lysosome and related protein degradation technologiesClick Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? Unraveling the diversity of molecular glue degraders
