May 2023 HighlightsBy Anonymous / April 28, 2023 Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics Underlying Catalytic Efficiency Discovery of novel protein degraders based on bioorthogonal reaction-driven intracellular self-assembly strategySynthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell linesBifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell DeathDiscovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo BRD4-targeting PROTAC as a unique tool to studybiomolecular condensatesFragment Linker Prediction Using the Deep Encoder-Decoder Network for PROTACs Drug Design Small-Molecule Ferritin Degrader as a Pyroptosis InducerDiscovery of estrogen receptor α targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor ProteinsBifunctional robots inducing targeted protein degradation Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategyStructure-activity relationship study of RSL3-based GPX4 degraders and its potential noncovalent optimization Novel Medicinal Chemistry Strategies Targeting CDK5 for Drug Discovery