June 2023 HighlightsBy Anonymous / June 7, 2023 Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field Physicochemical Property Determinants of Oral Absorption for PROTAC Protein DegradersDevelopment of PROTAC degrader probe of CDK4/6 based on DCAF16 Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen ReceptorDiscovery of Exceptionally Potent, Selective, and Efficacious PROTAC Degraders of CBP and p300 Proteins Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry†Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexeshttps://doi.org/10.1021/acschembio.2c00902 PROTACs: A novel strategy for cancer drug discovery and developmentDiscovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy Design and synthesis of proteolysis-targeting chimeras (PROTACs) as degraders of glutathione peroxidase 4Author links open overlay panelBioorthogonal PROTAC Prodrugs Enabled by On-Target Activation Recent Advances in Pro-PROTAC Development to Address On-Target Off-Tumor ToxicityChemically induced degradation of epigenetic targets† Mitochondrial Protease Targeting Chimeras for Mitochondrial Matrix Protein DegradationDiscovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1 Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate CancerUncovering the Kinetic Characteristics and Degradation Preference of PROTAC Systems with Advanced Theoretical Analyses
