November 2023 HighlightsBy Anonymous / December 8, 2023 Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2)Cooperatively designed aptamer-PROTACs for spatioselective degradation of nucleocytoplasmic shuttling protein for enhanced combinational therapy† Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic CancerMolecular glues targeting GSPT1 in cancers: A potent therapy Discovery of a selective TC-PTP degrader for cancer immunotherapy†Kinetic Modeling of PROTAC-Induced Protein Degradation Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand ChemotypeCovalent PROTAC design method based on a sulfonyl pyridone probe† Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane ProteinsCovalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACsRecent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive ChemistryIntegrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs Glutathione-responsive PROTAC for targeted degradation of ERα in breast cancer cellsClick Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction MixturesDiscovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged InhibitorsDiscovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase Kinetic Modeling of PROTAC-Induced Protein DegradationGenetic retargeting of E3 ligases to enhance CAR T cell therapy Discovery of Molecular Glue Degraders via Isogenic Morphological ProfilingDiscovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia
