October 2023 HighlightsBy Anonymous / October 30, 2023 Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry Targeted Protein Degradation Mediated by Genetically Engineered Lysosome-Targeting ExosomesATNC: Versatile Nanobody Chimeras for Autophagic Degradation of Intracellular Unligandable and Undruggable Proteins Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular SelectivityConjugation with glucagon like peptide-1 enables targeted protein degradation Discovery of a SHP2 Degrader with In Vivo Anti-Tumor ActivityExpanding PROTACtable genome universe of E3 ligases Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-MutationElucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras Rational Screening for Cooperativity in Small-Molecule Inducers of Protein–Protein AssociationsRational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3Methotrexate-based PROTACs as DHFR-specific chemical probes Targeting cancer with small molecule pan-KRAS degraders
