August 2023 HighlightsBy Anonymous / August 28, 2023 The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation Discovery of X10g as a selective PROTAC degrader of Hsp90α protein for treating breast cancerStructural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5 PROTAC for agriculture: learning from human medicine to generate new biotechnological weed control solutionsTargeted Degradation of CDK4/6: An Innovative Approach to Overcoming Cancer Drug Resistance Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyveTargeted Protein Degradation: Advances, Challenges, and Prospects for Computational Methods The application of PROTAC in HDACAn E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes Molecular mechanism for activation of the 26S proteasome by ZFAND5Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 Second-Generation AUTACs for Targeted Autophagic DegradationDesign, synthesis, and evaluation of BTK-targeting PROTACs with optimized bioavailability in vitro and in vivo† Opportunities and challenges of protein-based targeted protein degradationDevelopment of a Highly Potent and Selective Degrader of LRRK2
