July 2023 HighlightsBy Anonymous / July 8, 2023 The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradationDiscovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation Unlocking the potential of PROTACs: A comprehensive review of protein degradation strategies in disease therapyTracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization ROTACs leverage signaling-incompetent R-spondin for targeted protein degradationDesign and synthesis of a fluorescent probe to develop a fluorescence polarization assay for the E3 ligase FEM1C Design and synthesis of proteolysis-targeting chimeras (PROTACs) as degraders of glutathione peroxidase 4A degron blocking strategy towards improved CRL4CRBN recruiting PROTAC selectivity A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase-based Partial PROTAC LibraryExpanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes Discovery of highly potent HDAC8 PROTACs with anti-tumor activityRAS degraders: The new frontier for RAS-driven cancers Clinical Translation of Targeted Protein Degraders A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2)Reversible Assembly of Proteolysis Targeting Chimeras Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets
