Clinic - Protein Degraders

PROTACS

PROTAC DEGRADER	TARGET – LIGASE	INDICATION	COMPANY	STATUS	ROUTE
ARV-110 Bavdegalutamide	AR – CRBN	PROSTATE CANCER	ARVINAS	PHASE II	ORAL
ARV-471	ER – CRBN	BREAST CANCER	ARVINAS/PFIZER	PHASE II	ORAL
ARV-766	AR – —	PROSTATE CANCER	ARVINAS	PHASE I	ORAL
BGB-16673	BTK – CRBN	B-CELL MALIGNANCIES	BEIGENE	PHASE I	UNDISCLOSED
KT-474	IRAK4 – CRBN	AUTOIMMUNE	KYMERA/SANOFI	PHASE I	ORAL
KT-413	IRAK4 – CRBN	NHL	KYMERA	PHASE I	IV
KT-333	STAT3 – —	LIQUID AND SOLID TUMORS	KYMERA	PHASE I	IV
CC-94676	AR – CRBN	PROSTATE CANCER	BMS	PHASE I	ORAL
NX-2127	BTK – CRBN	B-CELL MALIGNANCIES	NURIX	PHASE I	ORAL
NX-5948	BTK – CRBN	B-CELL MALIGNANCIES	NURIX	PHASE I	ORAL
DT2216	BCLXL – VHL	LIQUID AND SOLID TUMORS	DIALECTIC THERAPEUTICS	PHASE I	IV
AC682	ER – CRBN	BREAST CANCER	ACCUTAR	PHASE I	ORAL
FHD-609	BRD9 – —	SYNOVIAL SARCOMA	FOGHORN	PHASE I	IV
CFT8634	BRD9 – CRBN	SYNOVIAL SARCOMA	C4 THERAPEUTICS	PHASE I	ORAL
CFT8919	EGFR – CRBN	NSCLC	C4 THERAPEUTICS	IND	ORAL
CG001419	TRK – CRBN	CANCER	CULLGEN	IND	ORAL
CFT1946	BRAF V600 – —	BRAF V600 mutant SOLID TUMORS	C4 THERAPEUTICS	PHASE I	ORAL
RNK05047	BRD4	SOLID TUMORS AND LYMPHOMA	RANOK	PHASEI/II	IV
AC176	AR	PROSTATE CANCER	ACCUTAR	PHASE I	ORAL
AC682	ER	BREAST CANCER	ACCUTAR	PHASE I	ORAL
HSK29116	BTK	B-CELL MALIGNANCIES	HAISCO	PHASE I	ORAL
HP518	AR	PROSTATE	HINOVA	PHASE I	ORAL
GT20029	AR	ACNE AND ALOPECIA	KINTOR	PHASE I	TOPICAL
ABBV-101	BTK	B-cell malignancies	ABBVIE	PHASE I	ORAL
JMKX002992	AR	PROSTATE CANCER	JEMINCARE/ROCHE	PHASE I	ORAL
ASP3082	KRASG12D	CANCER	ASTELLAS	PHASE I	IV
PRT3789	SMARCA2	CANCER	PRELUDE	PHASE I	IV
NX0497	IRAK4	RHEUMATOID ARTHRITIS	NURIX	IND	ORAL
KT253	MDM2	CANCER	KYMERA	PHASE I	IV

Molecular Glues

GLUE DEGRADER	TARGET – LIGASE	INDICATION	COMPANY	STATUS	ROUTE
CC-220 IBERDOMIDE	IKZF1/3-CRBN	MM	BMS	PHASE II/III	ORAL
CC-122 AVADOMIDE	IKZF1/3 – CRBN	SOLIDE TUMORS, MM, NHL	BMS	PHASE I	ORAL
CC-92480 MEZIGDOMIDE	IKZF1/3-CRBN	MM	BMS	PHASE II	ORAL
CC-90009 ERAGIDOMIDE	GSPT1-CRBN	AML	BMS	PHASE II	IV
CC-99282 GOLCADOMIDE	IKZF1/3-CRBN	CML, NHL	BMS	PHASE I	ORAL
BTX-1188	GSPT1/IKZF1-CRBN	ADVANCED MALIGNANCIES	BIOTHERYX	PHASE I	ORAL
CFT7455	IKZF1/3-CRBN	MM	C4 THERAPEUTICS	PHASE I	ORAL
DKY709	IKZF2	NSCLC	NOVARTIS	PHASE I	ORAL
MRT-2359	GSPT1-CRBN	MYC-DRIVEN TUMORS	MONTEROSA	PHASE I	ORAL
CC-91633	CK1A-CRBN	AML, MDS	BMS	PHASE I	ORAL

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